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Graphical presentation of CX-5461-mediated activation of the cytosolic DNA sensing pathway. cGAS binding on the cytosolic DNA activates the secondary messenger two,three-cGAMP making use of cGAS to be a catalyst. Activated STING buds from the ER moving on the perinuclear Golgi, where by it truly is palmitoylated.CX-5461 also induces global replicat